Subjective
• Numbness and tingling on the face or extremities*
• Fatigue
• Muscle weakness*
• Vertigo and tinnitus
• Paresthesias (burning, prickling)
• Blurred vision and diplopia*
• Urinary frequency, urgency, and urge incontinence*
• Sexual dysfunction
• Clumsiness
• Intolerance to heat
Objective
• Ataxia
• Nystagmus
• Dysphasia
• Tremors and spasticity of lower extremities
• Decreased perception to pain, touch, and temperature*
• Bladder and bowel incontinence
• Abnormal reflexes, including hyperreflexia, absent reflexes, and a positive Babinski reflex
• Emotional changes such as apathy, euphoria, irritability, and depression
• Weakness or paralysis of the legs, trunk, and head*
• Slurred speech and dysarthria; scanning speech