During a medication management class for nurses, the pharmacist discussing tricyclic antidepres-sants asked how these medications affect neurotransmitter activity. The nurse should respond:
1. "By decreasing available dopamine."
2. "By increasing availability of norepinephrine and serotonin."
3. "By making available increased amounts of monoamine oxidase."
4. "By increasing the effects of gamma-aminobutyric acid."
ANS: 2
Tricyclic antidepressants block neurotransmitter uptake, increasing the amounts of norepinephrine and serotonin available. 1. This is the action of typical antipsychotic medication. 3. This is not the action of tricyclics. 4. Benzodiazepines, not tricyclics, increase the effects of GABA.
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