Which of the following patterns describes the effect of repeated nicotine administration on the spontaneous motor activity (SMA) of rats?
a. Nicotine progressively depresses SMA in rats.
b. Nicotine progressively stimulates SMA in rats.
c. Nicotine initially depresses and subsequently stimulates SMA in rats.
d. Nicotine initially stimulates and subsequently depresses SMA in rats.
e. Nicotine has no effect on SMA in rats.
Answer: C
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