Orlistat (Alli) is initiated for a client with obesity who is taking warfarin. What health teaching would be most appropriate for this drug?
1. If you overeat, you may take more medication to counteract your indulgence.
2. You may resume your normal dietary habits while taking this drug.
3. You will need to closely monitor prothrombin time (PT) and international normalized ratio (INR).
4. Take the medication each evening 2 hours before taking warfarin.
Correct Answer: 3
Rationale 1: Orlistat (Alli) should be taken only as prescribed. More is not better.
Rationale 2: Changes in dietary consumption are critical for the medication to be effective.
Rationale 3: Monitor prothrombin time (PT) and international normalized ratio (INR) if the client is taking warfarin and orlistat (Alli) because the two medications have been known to interact.
Rationale 4: Orlistat must be taken with each meal. The timing of the warfarin dose is insignificant.
Global Rationale: Monitor prothrombin time (PT) and international normalized ratio (INR) if the client is taking warfarin and orlistat (Alli) because the two medications have been known to interact. Orlistat must be taken with each meal as directed. Additional medication is not indicated. Changes in dietary consumption are critical.
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