Describe the case of the child with no leptin

What will be an ideal response?


> normal weight at birth, but soon began to increase at an excessive rate
> demanded food continually and was disruptive when denied food
> as a result of her extreme obesity, deformities of her legs developed, and surgery was required
> 9 yrs of age when referred for treatment
>> weighed 210 pounds at this point, and was still increasing at an alarming rate
>found to be homozygous for ob been and had no detectable leptin, thus leptin therapy was commenced
> leptin therapy immediately curtailed the weight gain
>> began to eat less, and lost weight steadily over the 12-month period of the study (about 36 pounds) almost all in the form of fat
>

Biology & Microbiology

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