All of the following are true concerning hematopoietic stem cells except:
a. They express both CD34 and CD117 (c-kit).
b. They lose some antigens as they mature.
c. They express both CD4 and CD34.
d. They gain lineage-specific antigens as they mature.
ANS: C
CD4 is a marker of T cells, not hematopoietic stem cells (HSCs). HSCs express both CD34 and CD117 (c-kit). As they mature, some antigens are lost while lineage-specific antigens are gained.
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