A very large gene, such as DMD, may take hours to transcribe mainly because

a. RNA polymerase may have difficulty clearing the promoter.
b. long mRNAs form secondary structures that interfere with transcription.
c. RNA polymerase has time-consuming error correction activity.
d. many histone octamers may need to be modified or disassembled.
e. there may be multiple abortive attempts at transcription.


Ans: d

Biology & Microbiology

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