Which of the following diuretics is the most ototoxic?
A) ethacrynic acid
B) chlorothiazide
C) methyclothiazide
D) acetazolamide
A) ethacrynic acid
Ethacrynic acid is the most ototoxic diuretic. Loop diuretics, which include ethacrynic acid, are toxic to the ear, particularly when used in conjunction with the aminoglycoside antibiotics. Irreversible damage may result with continued treatment using ethacrynic acid.
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