A client with Cushing syndrome is prescribed ketoconazole (Nizoral). What should the nurse explain as the reason for this medication?
1. "This medication will prevent infections."
2. "Cushing syndrome is caused by an infection of the adrenal glands, and the medication will reverse the disease process."
3. "This drug blocks the formation of glucocorticoids, lowering their level in your blood."
4. "This has been prescribed because you have a fungal infection."
Correct Answer: 3
Rationale 1: This is not the reason this medication is prescribed for a client with Cushing syndrome.
Rationale 2: Cushing syndrome is not caused by an intra-adrenal infection.
Rationale 3: Ketoconazole rapidly blocks the synthesis of glucocorticoids, lowering serum levels. It is considered an antiadrenal agent and is the drug of choice for clients with Cushing disease needing long-term therapy.
Rationale 4: This is not the reason this medication is prescribed for a client with Cushing syndrome.
Global Rationale: Ketoconazole rapidly blocks the synthesis of glucocorticoids, lowering serum levels. It is considered an antiadrenal agent and is the drug of choice for clients with Cushing disease needing long-term therapy. It does not prevent or treat infection. Cushing syndrome is not caused by infection. The patient is not receiving the medication for a fungal infection, however it is used for that purpose as well.
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