Aldosterone is a hormone secreted by the adrenal cortex, and insulin is a peptide secreted by the pancreas

When aldosterone contacts a target cell, it binds to an intracellular receptor
and migrates to the nucleus; insulin binds to extracellular receptors on the plasma
membrane. What is the most likely reason for this difference?
A. Aldosterone is hydrophilic and therefore
must enter the aqueous environment of the
cytoplasm to have an effect.
B. Aldosterone is lipid-soluble and therefore
easily crosses the phospholipid bilayer of the
plasma membrane.
C. Aldosterone is too small to bind
extracellular receptors on the plasma
membrane.
D. Insulin is too large to interact with DNA.


B

Biology & Microbiology

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