Which immunoglobulin isotypes (out of IgM, IgG1, IgG2, IgG3, IgG4, IgA, IgE, and IgD) participate in
(a) neutralization; (b) opsonization; (c) sensitization for killing by NK cells; (d) sensitization of mast cells; (e) activation of complement? Which isotypes (f) are transported across epithelium; (g) are transported across the placenta; (h) diffuse into extravascular sites?
A. Neutralization: IgM, IgG1, IgG2, IgG3, IgG4, IgA
B. Opsonization: IgG1, IgG2, IgG3, IgG4, IgA
C. Sensitization for killing by NK cells: IgG1, IgG3
D. Sensitization of mast cells: IgG1, IgG3, IgE
E. Activation of complement: IgM, IgG1, IgG2, IgG3, IgA
F. Transport across epithelium: IgM, IgA (dimer)
G. Transport across placenta: IgG1, IgG2, IgG3, IgG4
H. Diffusion into extravascular sites: IgM, IgG1, IgG2, IgG3, IgG4, IgA (monomer), IgE
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