Rapid immunological assays for Group A Streptococcus pyogenes antigen have a sensitivity of
about 60% to 80% and a specificity of about 90% to 95% in pharyngitis infections. Given these
data, which strategy below is optimal?
A) Do preliminary screening with a throat culture and follow up positive results with a rapid
antigen test.
B) Do preliminary screening with a rapid antigen test and follow up negative results with a
throat culture.
C) Do preliminary screening with a rapid antigen test and follow up positive results with a
throat culture.
D) Do preliminary screening with a throat culture and follow up negative results with a rapid
antigen test.
E) Simultaneously test all specimens with both rapid antigen screening and culture.
B
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