A family has had all five of their children born with a genetic disorder. The disorder is inherited as autosomal dominant. If this is not a statistical rarity, the likelihood would be that:
1. Both parents are carriers.
2. One parent is a carrier and the other parent is unaffected.
3. One parent has both chromosomes with the affected gene.
4. One parent has one chromosome affected and the other parent has none.
3
Rationale:
1. If both parents are carriers, 25% of the children should be free of the disease.
2. For all five children to have the disorder, one parent would have to have both chromosomes affected.
3. It takes only one chromosome to cause the defect in the child. If one parent has both chromosomes affected, every child would receive the affected chromosome.
4. For all five children to have the disorder, one parent would have to have both chromosomes affected.
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