A nursing student asks a nurse to explain the differences between amphotericin B (Abelcet) and the azoles group of antifungal agents. Which statement by the nurse is correct?
a. "Amphotericin B can be given orally or intravenously ."
b. "Amphotericin B increases the levels of many other drugs."
c. "Azoles have lower toxicity than amphotericin B."
d. "Only the azoles are broad-spectrum antifungal agents."
ANS: C
The azoles class of antifungals is less toxic than amphotericin B. Amphotericin B may only be given parenterally. The azoles, not amphotericin B, inhibit hepatic P450 drug-metabolizing enzymes, so they increase the levels of many other drugs. Both classes are broad-spectrum antifungal agents.
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