What is the action of pentoxifylline (Trental), a hemorheologic agent used to treat chronic occlusive arteriole disease?
a. Vasodilates the peripheral arteries
b. Potentiates the blood-clotting mechanism
c. Increases erythrocyte flexibility
d. Increases blood viscosity
ANS: C
Pentoxifylline enhances red blood cell (erythrocyte) flexibility, which reduces blood viscosity. This allows for more blood to perfuse into the tissues. Muscle tissues become better oxygenated and intermittent claudication is reduced. Pentoxifylline does not cause vasodilation. Pentoxifylline acts to decrease clotting and decreases blood viscosity.
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