Which of the following would most likely contribute to uncontrolled cell proliferation (i.e., cancer)?

A. a mutant CDK that was active in the
absence of its cyclin binding partner
B. a mutant cyclin that cannot bind to its
normal CDK binding partner
C. a mutant microtubule
synthesis/polymerization enzyme
D. a mutant DNA replication mechanism
causing extra chromosome copies
E. a mutant kinetochore protein that causes
reduced microtubule attachment


A

Biology & Microbiology

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