Which substance produces a response equal to or greater than the effects of an endogenous chemical in the body?
a. Competitive inhibitor
b. Noncompetitive inhibitor
c. Antagonist
d. Agonist
ANS: D
Agonists combine with receptors to initiate events; that is, they have intrinsic activity that is produced by two different mechanisms. Agonist I drugs bind to the same site as an endogenous substance (e.g., neurotransmitter) to produce a similar response. The response usually equals, or is greater than, that of the endogenous substance. Agonist II drugs bind to different extracellular sites, with no response produced solely in the presence of the agonist. However, an enhanced re-sponse is generated when an existing endogenous substance also binds to its site.
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