A patient is admitted for treatment of gout that has been refractory to treatment with allopurinol and probenecid. The patient is taking colchicine, and the prescriber orders pegloticase [Krystex-xa]
Before administering this drug, the nurse will expect to: a. administer an antihistamine and a gluco-corticoid.
b. discontinue the colchicine.
c. increase the dose of colchicine.
d. prepare to administer a bronchodilator if needed.
A
Because pegloticase poses a risk of triggering anaphylaxis, patients should be pretreated with an antihistamine and a glucocorticoid. Colchicine is indicated at the initiation of treatment with pegloticase to reduce the intensity of gout flare-ups. Bronchodilators are not indicated.
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