Which of the following drugs is the angiotensin-converting enzyme (ACE) inhibitor of choice for slowing progression of chronic renal failure (CRF) to end-stage renal disease (ESRD)?
a. Captopril (Capoten)
b. Benazepril (Lotensin)
c. Enalapril (Vasotec)
d. Lisinopril (Prinivil)
ANS: A
The most commonly used ACE inhibitor approved by the Food and Drug Administration (FDA) for management of patients with CRF or ESRD is captopril. It blocks the conversion of angio-tensin I to angiotensin II, which reduces efferent arteriolar vasoconstriction and normalizes blood pressure.
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