Which patient should receive dantrolene (Dantrium) with caution?
a. A 20-year-old woman with a spinal cord injury
b. A 45-year-old man with a history of malignant hyperthermia
c. A 55-year-old woman with multiple sclerosis
d. An 8-year-old child with cerebral palsy
ANS: C
Dose-related liver damage is the most serious adverse effect of dantrolene and is most common in women older than 35 years. Dantrolene is used to treat spasticity associated with multiple sclerosis, cerebral palsy, and spinal cord injury, so all of these patients would be candidates for this agent. Dantrolene also is used to treat malignant hyperthermia.
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