A hospital client has been experiencing agitation and has consequently been prescribed a one-time dose of lorazepam that is to be administered sublingually

The nurse knows that this route of administration will result in a rapid onset and peak because A) Saliva potentiates (increases) the therapeutic effect of the drug
B) The drug is absorbed at a location that is close to the central nervous system
C) The drug bypasses the effects of digestive enzymes
D) The drug is rapidly absorbed by the rich blood supply under the tongue


D
Feedback:
A tablet given by sublingual application (drug placed under the tongue) is left to dissolve slowly and become absorbed by the rich blood supply in the area. Sublingual administration is made effective by virtue of proximity to the CNS, the potentiating effect of saliva or avoidance of digestive enzymes.

Nursing

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