To exert its effects on gene regulation in a cell, a steroid hormone must interact with a variety of proteins and cell structures along the way. Check the box for each interaction partner.
_____ carrier protein
_____ microtubules
_____ plasma membrane
_____ hormone receptor
_____ nuclear membrane
_____ GPCR
Clarify Question
What is the key concept addressed by the question?
What type of thinking is required?
Gather Content
What do you already know about steroidhormones? What other information is related to the question?
Choose Answer
Given what you now know, what information is most likely to produce the correct answer?
Reflect on Process
Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
__X__ carrier protein
_____ microtubules
__X__ plasma membrane
__X__ hormone receptor
__X__ nuclear membrane
_____ GPCR
Clarify Question
What is the key concept addressed by the question?
· What do steroid hormones interact with?
What type of thinking is required?
o This is an analyze question because you have to understand the complete process of steroid hormone-induced gene regulation and the other key structures in the process.
Gather Content
What do you already know about steroidhormones? What other information is related to the question?
· Steroid hormones, because they are lipophilic, must be carrier through the blood on special carrier proteins. When they arrive at the tissues, they dissociate from their carrier and diffuse across the phospholipid bilayer of cells. Once within the cell, the steroid binds to receptors and form hormone-receptor complexes that then bind to hormone response elements on the DNA after passing into the nucleus through nuclear pores. The hormone-receptor complex regulates the production of messenger RNA for specific proteins.
Choose Answer
Given what you now know, what information is most likely to produce the correct answer?
· Carrier proteins are needed to transport steroid hormones because it makes them soluble and prolong their survival in the blood. Microtubules are not needed for steroids to affect gene expression. Lipophilic hormones diffuse across the plasma membrane of the cell. Once inside the cell, they must bind to hormone receptors. Then this hormone-receptor complex passes through the nuclear membrane through nuclear pores. GPCR are used with peptide hormones, not steroid hormones.
Reflect on Process
Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
· Answering this question correctly depended upon analyzing each potential molecular/cellular structures to see if they are sensible interaction partners for steroid hormones. If you got the answers correct, great! If not, which answer did you choose? Did you know that microtubules are used to transport materials around cells and that steroid hormones need to move from outside the cell to inside the nucleus, so you thought that microtubules would be the answer? With special receptor proteins for transport into the nucleus, microtubules are not needed. Since hormones bind to receptors, and you knew that GPCR are hormone receptors, did you think GPCR was a correct answer? GPCR bind to peptide hormones outside the cell, not steroid hormones inside the cell.
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