What is the mechanism that underlies caffeine’s capacity to alleviate headache?
a. Caffeine stimulates the production of nitric oxide in endothelial cells.
b. Caffeine stimulates the release of endogenous opioids, which have analgesic action.
c. Caffeine dilates cerebral blood vessels.
d. Caffeine produces vasoconstriction and reduces cerebral blood flow.
e. None of the above are true. Caffeine has no capacity to alleviate headache.
Answer: D
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