Give two pieces of evidence that support the catecholamine hypothesis of depression and one piece of evidence that seems to conflict with the hypothesis
What will be an ideal response?
The actions and behavioral effects of reserpine, MAOIs, amphetamine, and monoamine reuptake blockers are superficially compatible with the hypothesis, because these either deplete or enhance synaptic catecholamine levels, and correspondingly induce or reduce symptoms of depression. However, the lack of correspondence between the onset of drug action and the drugs' clinical efficacy, i.e., the fact that MAOIs and many antidepressants enhance synaptic catecholamine levels rapidly (typically within hours) but exert their benefits in depressed individuals fairly slowly (typically within several days or weeks), is a problem for the hypothesis. Also, clinically effective catecholamine-augmenting antidepressants only elevate mood in depressed individuals. Also, the SSRIs, which have minimal influence on catecholamines, are just as effective as antidepressants as drugs that are potent catecholamine reuptake blockers.
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a. equally weighted. b. unequally weighted. c. age restricted. d.
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a. Geneva b. Leipzig c. London d. Paris
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A) shorter B) thinner C) thicker D) denser
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a. True b. False