A nurse who works in an outpatient chemotherapy unit has received an order to administer filgrastim (Neupogen) to a client who received chemotherapy this morning

The client's white blood cell count is dropping rapidly. The nurse asks the client to return to the unit tomorrow for the filgrastim. What is the rationale for the nurse's request?
1. If given today, the increase in the white blood cell count will occur too rapidly.
2. The actions of the filgrastim and chemotherapy drugs will oppose each other.
3. If the filgrastim is given today, the risk of liver damage will increase.
4. There is an increased risk of adverse reaction to both drugs.


Correct Answer: 2
Rationale 1: The white cell count will not increase rapidly, and it might not increase at all.
Rationale 2: Because antineoplastic drugs and CSFs produce opposite effects, filgrastim is not administered until at least 24 hours after a chemotherapy session.
Rationale 3: There is no increase in the risk of liver damage if these two drugs are given closely together.
Rationale 4: Both drugs have adverse reactions, but they do not potentiate each other.
Global Rationale: Because antineoplastic drugs and CSFs produce opposite effects, filgrastim is not administered until at least 24 hours after a chemotherapy session. The white cell count will not increase rapidly, and it might not increase at all. There is no increase in the risk of liver damage if these two drugs are given closely together. Both drugs have adverse reactions, but they do not potentiate each other.

Nursing

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