John has alkaptonuria; it "runs in the family". John and his grandmother are both homozygous for alkaptonuria. John's grandmother has two brothers and a sister. One of the brothers had alkaptonuria and his daughter is John's mother. Based on this information, John's parents are:
a. Both homozygous for the alkaptonuria gene.
b. Both heterozygous for the alkaptonuria gene.
c. Not carrying the alkaptonuria gene.
d. There isn’t enough information.
Answer: b. Both heterozygous for the alkaptonuria gene.
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