What is the central mechanism for establishing self-tolerance?

A. Self-reactive T cells and B cells are killed during development.
B. Individuals that have immune systems that respond to self-antigens do not survive to reproduce.
C. Immune cells that react to self-antigens are turned off when they recognize self-tissues.
D. Certain immune suppressive cytokines are maintained in tissues to dampen auto reactive immune responses.
E. Peripheral tissues have mechanisms to kill T or B cells that respond to them.


A

Health & Biomechanics

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