Factors that affect the pharmacokinetics of lipophilic medications in older include:
a. greater adipose tissue ratio to body mass
b. decreased total body water
c. increased glomerular filtration rate
d. increased creatinine clearance
ANS: A
Older adults have a higher ratio of adipose (fat) tissue where lipophilic (fat soluble) medica-tions can be stored thus resulting in a potential for an accumulation of the medication and potentially fatal overdoses. Older adults have a decrease in lean body mass and an increase in fat. An increased body mass would not affect lipophilic medication absorption. Older adults have a decreased glomerular filtration rate, which begins to decline as early as age 25. Older adults have a decrease in overall kidney function.
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