A cancer patient has been prescribed 5-fluorouracil, an antimetabolite chemotherapy agent. This medication stops normal development and division by interrupting the S-phase of the cell cycle
When teaching this patient, the nurse explains that during the S-phase of the cell cycle,
A)
the cell is in a prolonged resting state and only leaves this state when cellular destruction is occurring.
B)
the DNA synthesis stops, but RNA synthesis continues.
C)
nuclear division occurs.
D)
the synthesis of DNA occurs, causing two separate sets of chromosomes to develop.
Ans:
D
Feedback:
During the S-phase, DNA synthesis occurs, causing two separate sets of chromosomes to develop. Antimetabolites can cause abnormal timing of DNA synthesis. Because of their S-phase specificity, the antimetabolites are more effective when given as a prolonged infusion.
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