A patient starting therapy with efavirenz [Sustiva] asks about the timing of the medication with regard to meals. What patient education about the administration of this medication should the nurse provide?
a. The drug must be taken within 30 minutes after a meal.
b. The drug is best taken with a high-fat meal.
c. The drug can be taken anytime without regard to meals.
d. The drug should be taken once daily on an empty stomach.
D
The nurse should advise the patient that the medication should be taken once daily on an empty stomach. Thirty minutes after a meal is too soon to take the medication. The medication is taken on an empty stomach, because high-fat meals increase plasma levels by 39% with capsules and by 79% with tablets. The medication must not be taken with high-fat meals.
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