Discuss antimicrobial susceptibility testing and the use of minimal inhibitory concentration (MIC) values

What will be an ideal response?


Answer: Antimicrobial susceptibility is measured by determining the smallest amount of agent needed to completely inhibit the growth of the test organism in vitro. This value is called the minimum inhibitory concentration (MIC). The MIC is determined by preparing a series of culture tubes that are inoculated with the same number of microorganisms. Each tube contains liquid medium with increasing concentration of the antimicrobial agent. After incubation, the tubes are checked for visible growth. This is usually completed using an automated format. A miniaturized version of this test shows a standard microtiter method using twofold dilutions of several antibiotics in medium inoculated with a standard amount of the test bacteria.

Biology & Microbiology

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Biology & Microbiology