A nurse is caring for a patient who is receiving amphotericin B (Abelcet) for a systemic fungal infection. In spite of receiving diphenhydramine and acetaminophen before initiation of treatment, the patient has fever and chills with rigors
The nurse will contact the provider to discuss the addition of which drug?
a. Aspirin
b. Dantrolene
c. Hydrocortisone
d. Omeprazole
ANS: B
Patients receiving amphotericin frequently experience infusion reactions, with fever, chills, rigors, nausea, and headache. Pretreatment with diphenhydramine and acetaminophen can reduce mild reactions. If rigors occur, the patient should receive dantrolene or meperidine. Aspirin would be effective for pretreatment but can increase kidney damage. Hydrocortisone is also effective, but it causes immune suppression. Omeprazole is not indicated.
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