A child who receives valproic acid [Depakote] begins taking lamotrigine [Lamictal] because of an increase in the number of seizures. The nurse will observe this child closely for which symptom?
a. Angioedema
b. Hypohidrosis
c. Rash
d. Psychosis
C
Lamotrigine can cause life-threatening rashes, such as Stevens-Johnson syndrome and toxic epi-dermal necrolysis, and this risk increases with concurrent use of valproic acid. Angioedema is an adverse effect associated with pregabalin. Hypohidrosis and psychosis are associated with topi-ramate.
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