Summarize Fredrick Griffith's, Oswald Avery's, and others' experimental search for a treatment for pneumonia

What will be an ideal response?


Griffith discovered that the ability to cause pneumonia is a genetic trait that can be passed from one strain of bacteria to another. Griffith isolated two strains of Streptococcus pneumoniae. One strain was surrounded by a capsule that allowed it to evade the immune system and cause pneumonia. Griffith called this strain S. The other strain was not surrounded by a capsule and did not cause pneumonia. Griffith called this strain R. He found that mice injected with strain R do not develop pneumonia and mice injected with strain S develop pneumonia and die. Furthermore, when the S strain cells are killed by heat treatment before injection, mice do not develop pneumonia. Griffith discovered that when mice are injected with a mixture of heat-killed S cells and live R cells, they develop pneumonia and die. Avery concluded that DNA from the dead S cells was responsible for transforming the R cells into S cells.

Biology & Microbiology

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