The nurse would question the use of amphotericin B in the client concurrently receiving which medication?
1. Actos
2. Vancomycin
3. Captopril
4. Coumadin
Correct Answer: 2
Rationale 1: Actos is used to treat type II diabetes, and is not contraindicated for concurrent use of amphotericin B.
Rationale 2: Drug interactions with amphotericin B focus on worsening two of its potentially serious adverse effects: nephrotoxicity and hypokalemia. For example, concurrent therapy with aminoglycosides, cyclosporine, vancomycin, carboplatin, and furosemide is not recommended.
Rationale 3: Captopril is not contraindicated for concurrent use of amphotericin B.
Rationale 4: Coumadin is not contraindicated for concurrent use of amphotericin B.
Global Rationale: Drug interactions with amphotericin B focus on worsening two of its potentially serious adverse effects: nephrotoxicity and hypokalemia. For example, concurrent therapy with aminoglycosides, cyclosporine, vancomycin, carboplatin, and furosemide is not recommended. The other drugs present no contraindication.
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