The acceptable range for osmolality of serum is
a) 280 to 298 mOsm/kg
b) 160 to 300 mOsm/kg
c) <180 mOsm/kg
d) 300to350mOsm/kg
Ans: a) 280 to 298 mOsm/kg
• Osmolality-a measure of the osmoles of solute per kilogram of solvent (osmol/kg or Osm/kg)
• Plasma osmolality is a measure of the concentration of substances such as sodium, chloride, potassium, urea, glucose, and other ions in blood. It is calculated as the osmoles of solute per kilogram of solvent.
• Cell membranes are freely permeable to water, therefore the osmolality of the extracellular fluid (ECF) is approximately equal to that of the intracellular fluid (ICF), plasma osmolality is a guide to intracellular osmolality. This is important, as it shows that changes in ECF osmolality have a great affect on ICF osmolality - changes that can cause problems with normal cell functioning and volume. If the ECF was to become too hypotonic, water would readily fill surrounding cells, increasing their volume and potentially lysing them
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