Which statement is true regarding grading of cancer cells?
1. Grading has very few limitations, as tumors contain cell types that are similar in appearance.
2. If the biopsy cells appear differentiated and similar to parent cells, the tumor receives a grade of 1.
3. Grading does not change much over time as the tumor evolves.
4. If the biopsy cells appear differentiated and similar to parent cells, the tumor receives a grade of 4.
Correct Answer: 2
Rationale 1: Grading has certain limitations, as tumors contain many different types of cells that vary in appearance.
Rationale 2: This is true regarding grading.
Rationale 3: Grading changes over time as the tumor evolves.
Rationale 4: If the tumor cells are similar to parent cells, a grade of 1 is given, not a grade of 4.
Global Rationale: In the grading process, if the biopsy cells appear differentiated and very similar to the parent cells, the tumor is classified as a Grade 1 (G1) and has the best prognosis. Grading has certain limitations. For instance, solid tumors often contain many different types of cells that vary in appearance from near normal to grossly abnormal. One part of the tumor may have cells consistent with G2, whereas other parts of the same tumor may have cells consistent with G4. Unlike staging, grading may change over time as the tumor evolves. G4 cells are grossly abnormal and clearly different from normal cells.
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