A patient who has been taking cyclosporine to prevent rejection of a kidney transplant has had diltiazem ordered. Why would the nurse question this order?
A) Serious diltiazem toxicity could occur.
B) The combination may result in elevated or even toxic cyclosporine levels.
C) The combination could lead to kidney rejection.
D) A kidney recipient would not effectively excrete the diltiazem.
B
Feedback:
Potentially serious adverse effects to keep in mind include increased serum levels and toxicity of cyclosporine if they are taken with diltiazem. This combination is not associated with diltiazem toxicity. A functioning implanted kidney should still excrete diltiazem. This drug would not cause rejection of a transplanted kidney.
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