Why is heme located inside a globin chain pocket surrounded by hydrophobic amino acids?
a. Protects iron from being oxidized to its ferric form
b. Necessary for oxygen release to tissues
c. Makes hemoglobin insoluble
d. Keeps heme from being dissolved
ANS: A
This arrangement helps keep iron in the divalent (ferrous) form regardless of whether or not it is carrying oxygen. This is critical for hemoglobin's ability to reversibly bind oxygen.
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