Comparison of proteins from normal muscle cells and cells derived from a fibrosarcoma is performed using two-dimensional gel analysis
The gel with normal muscle cells shows one large protein, FS, which disappears from the gel with the fibrosarcoma cell lysates. Two smaller proteins (P1 and P2) have appeared in the fibrosarcoma cells. Mass spectrophotometry of FS, P1, and P2 indicates that the new smaller proteins have sequences that match the protein FS; if combined, their sizes would be equivalent to protein FS. With these results, which of the following could be a reasonable conclusion?
A. Protein FS been covalently modified by phosphorylation in fibrosarcoma cells.
B. P1 and P2 cause fibrosarcoma.
C. Intact FS insures normal cell function.
D. Cleavage of FS to P1 and P2 may be associated with fibrosarcoma.
E. There is a mutated form of FS in fibrosarcoma patients.
D
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