A patient has lamivudine-sensitive hepatitis B and is taking entecavir (Baraclude) 0.5 mg per day. The nurse reviews the patient's laboratory values and notes a creatinine clearance of 40 mL/min
What will the nurse discuss with the patient's provider?
a. Continuing the entecavir at the same dose
b. Decreasing the entecavir dose to 0.25 mg per day
c. Discontinuing the entecavir and considering dialysis
d. Increasing the entecavir dose to 1 mg per day
ANS: B
Patients with a creatinine clearance of 30 to 49 mL/min should take 0.25 mg of entecavir per day. It is not correct to continue the same dose or to increase the dose. Dialysis is not indicated.
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