A nurse counsels a couple on sex-linked disorders. Both are carriers of the disorder. They ask the nurse how this disorder will affect any children they might have. The nurse's best response is:
1. "If you have a daughter, she will not be affected."
2. "Your son will be affected, since the father has the disorder."
3. "There is a 25% chance that your son will have the disorder, since the mother has the disorder."
4. "There is a 50% chance that your son will be a carrier only."
4
Rationale:
1. There is a 50% chance that a carrier mother will pass the abnormal gene to each of her daughters, who will become carriers.
2. Fathers affected with a sex-linked disorder cannot pass the disorder to their sons, but all their daughters become carriers of the disorder.
3. There is a 50% chance that a carrier mother will pass the abnormal gene to each of her sons, who will be affected.
4. There is a 50% chance that a carrier mother will pass the normal gene to each of her sons, who will be unaffected.
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