What factors can affect drug absorption? (Select all that apply.)
1. Blood pressure
2. Laboratory values
3. Heart rate
4. Weight
1, 2, 3
Rationale 1: Blood pressure can affect drug absorption. If the blood pressure is low, circulation and absorption are impaired.
Rationale 2: Laboratory values can affect drug absorption as drugs may need to move across membranes to reach their target cells by way of electrolytes.
Rationale 3: Heart rate can affect drug absorption. If the heart rate is low, circulation and absorption are impaired.
Rationale 4: Weight is not a factor that affects drug absorption.
Global rationale: Absorption is the process that involves the movement of a substance from its site of administration across one or more body membranes. Circulation is responsible for the movement. If the circulation is impaired (low blood pressure or heart rate), then absorption is also impaired. Most drugs move across many membranes to reach their target cells.
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