You are a consultant with an architectural firm designing a BSL-3 hospital facility for patient care and diagnostic laboratory services. The facility will specialize in airborne pathogens such as Mycobacterium tuberculosis. Describe the characteristics

of pathogens handled in a BSL-3 facility and describe at least five features that must go into the facility design.

What will be an ideal response?


A BSL-3 facility handles pathogens which cause serious, sometimes lethal, human disease. Some pathogens in this category may be treatable. These pathogens may be contagious and transmitted through airborne routes, which means that the pathogen may remain infectious in the environment for some time. Besides all measures for BSL-1 and BSL-2 facilities, the BSL-3 facility should have: controlled access with self-closing double doors, airflow management such as airborne infection isolation rooms (AIIR) to keep airborne pathogens from other parts of the building, biological safety cabinets for pathogen handling and manipulation, decontamination facilities for waste and personal protective equipment that will be laundered, availability of gloves, protective lab coverings, and respirators for personnel which will remain in the BSL-3 facility, adequate warning signage detailing infection risks, and available vaccination and/or monitoring of personnel for infection.

Biology & Microbiology

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