The nurse is caring for a client who is prescribed laxatives. Which statements are most relevant to the absorption of medications?
1. Drugs that increase peristalsis may decrease absorption.
2. Drugs that decrease peristalsis may increase absorption.
3. The presence of food will usually decrease absorption.
4. Drug–drug interactions that affect absorption may be prevented by taking the drugs 2 hours apart.
5. Increasing fluid intake will increase absorption.
Correct Answer: 1,2,3,4
Rationale 1: The less time drugs stay in the stomach or small intestine, the less the time of absorption.
Rationale 2: The longer the drug is exposed to the stomach lining and small intestine, the greater the time of absorption.
Rationale 3: Absorption is increased when the stomach is empty.
Rationale 4: Many drug–drug interactions that cause decreased absorption can be avoided by separating the drugs by 2 to 3 hours.
Rationale 5: Increasing fluid intake will not affect absorption.
Global Rationale: The less time drugs stay in the stomach or small intestine, the less the time of absorption. The longer the drug is exposed to the stomach lining and small intestine, the greater the time of absorption. Absorption is increased when the stomach is empty. Many drug–drug interactions that cause decreased absorption can be avoided by separating the drugs by 2 to 3 hours. Increasing fluid intake will not affect absorption.
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