Why are calcium-channel blockers not used in all patients with idiopathic pulmonary artery hy-pertension?
a. It causes severe side effects.
b. Many of these patients have systemic hy-potension.
c. Only a small percentage of IPAH patients respond.
d. There is a high incidence of anaphylaxis.
ANS: C
Patients with IPAH who respond to vasodilators in the short term have improved survival with long-term use of calcium-channel blockers. Thus, these agents should be considered in all patients who have significant and definite response to a short-acting vasodilator. Unfortunately, only a small fraction of IPAH patients qualify for and benefit from long-term therapy with oral calci-um-channel blockers.
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