When fired inside the mouth, what percentage of the drug dose delivered by a simple metered dose inhaler (MDI) deposits in the oropharynx?
a. Approximately 20%
b. Approximately 40%
c. Approximately 60%
d. Approximately 80%
ANS: D
The initial velocity and dispersion of the aerosol plume generate larger particles that decrease in size as they leave the pressurized MDI, resulting in approximately 80% of the dose leaving the actuator to impact and become deposited in the oropharynx.
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