RNA viruses code for polymerases that do not proofread replicated viral chromosomes. Consequently, RNA viruses experience extremely high mutation rates

Whereas RNA viruses have mutation rates of about 1/10,000 base pairs per replication, their human hosts show mutation rates that by the same measure are at least 1 million times lower. Speculate on differences between vertebrates and viruses that led to the evolution of such widely diverging mutation rates.
a. DNA polymerases have a built-in proofreading function.
b. RNA viruses are so simple that virtually all mutations are neutral or adaptive.
c. Vertebrates compensate for low individual mutation rates via having large population sizes.
d. There is extensive pleiotropy in vertebrate genomes.


D

Biology & Microbiology

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