Which is a cause or trigger of malignant hyperthermia (MH)?
a. Excessive heat in the OR suite
b. Nondepolarizing muscle relaxants
c. Depolarizing skeletal muscle relaxants
d. Unexplained preoperative fever
ANS: C
Malignant hyperthermia (MH) is a hypermetabolic crisis in susceptible people. It is triggered by potent halogenated anesthetic agents and depolarizing skeletal muscle relaxants. Susceptible patients also include those with any type of myopathy or acquired muscle disease, such as ptosis, strabismus, hernia, muscle weakness or hypertrophy, or muscular dystrophy. The incidence of MH is higher in children than in adults. Patients, especially children, with rheumatoid arthritis are particularly susceptible to MH.
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