Mutating the gene Transformer (tra) in Drosophila that is chromosomally XX leads to the development of only males. Explain

What will be an ideal response?


In nonmutated fertilized eggs that are supposed to develop into females (XX), the two copies of SXL causes the expression of tra, which then leads to an alternative splicing pathway of the dsx gene that induces female development. However, even though sxl is present at levels to cause female development (because of the two X chromosomes), only males form because the SXL target is tra. If tra is not expressed or mutated, then males will form due to the alternative splicing of dsx that leads to male development.

Biology & Microbiology

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